Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice.
Identifieur interne : 000443 ( 2020/Analysis ); précédent : 000442; suivant : 000444Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice.
Auteurs : André Luis Fabris [Brésil] ; Andre Vinicius Nunes [Brésil] ; Viviane Schuch [Brésil] ; Marina De Paula-Silva [Brésil] ; Gho Rocha [Brésil] ; Helder I. Nakaya [Brésil] ; Paulo Lee Ho [Brésil] ; Eduardo L V. Silveira [Brésil] ; Sandra Helena Poliselli Farsky [Brésil]Source :
- Environmental pollution (Barking, Essex : 1987) [ 1873-6424 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- toxicité : Hydroquinones.
- Animaux, Immunité humorale, Mâle, Souris, Souris de lignée C57BL, Tabac, Vaccins antigrippaux.
English descriptors
- KwdEn :
- MESH :
- chemical , toxicity : Hydroquinones.
- drug effects : Immunity, Humoral.
- Animals, Influenza Vaccines, Male, Mice, Mice, Inbred C57BL, Tobacco.
Abstract
The influenza is a common viral infection that can be fatal, especially in high-risk groups such as children, pregnant women, elderly, and immune-deficient individuals. Vaccination is the most efficient approach to prevent the spreading of viral infection and promote individual and public health. In contrast, exposure to environmental pollutants such as cigarette smoke reduces the efficacy of vaccination. We investigated whether chronic exposure to hydroquinone (HQ), the most abundant compound of the tobacco particulate phase, could impair the adaptive immune responses elicited by influenza vaccination. For this, adult male C57BL/6 mice were daily exposed to either nebulized HQ or PBS for 1 h for a total of eight weeks. At weeks 6 and 8, the mice were primed and boosted with the trivalent influenza vaccine via IM respectively. Although the HQ exposure did not alter the body weight of the mice and the biochemical and hematological parameters, the pollutant increased the oxidative stress in splenocytes of immunized animals, modified the morphology of spleen follicles, and augmented the size of their lymph nodes. The lymphoid organs of HQ-exposed mice presented a similar number of vaccine-specific IgG-secreting cells, titers of vaccine-specific total IgG, and respective subclasses. Transcriptome studies with HQ, benzene, or cigarette smoke exposure were also analyzed. The genes up-regulated upon pollutant exposure were associated with neutrophil migration and were shown to be co-expressed with antibody-secreting cell genes. Therefore, these findings suggest that HQ exposure may trigger an immune-compensatory mechanism that enhances the humoral responses induced by influenza vaccination.
DOI: 10.1016/j.envpol.2019.113554
PubMed: 31767231
Affiliations:
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xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Experimental Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Nunes, Andre Vinicius" sort="Nunes, Andre Vinicius" uniqKey="Nunes A" first="Andre Vinicius" last="Nunes">Andre Vinicius Nunes</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Immunology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Immunology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Schuch, Viviane" sort="Schuch, Viviane" uniqKey="Schuch V" first="Viviane" last="Schuch">Viviane Schuch</name><affiliation wicri:level="4"><nlm:affiliation>Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="De Paula Silva, Marina" sort="De Paula Silva, Marina" uniqKey="De Paula Silva M" first="Marina" last="De Paula-Silva">Marina De Paula-Silva</name><affiliation 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São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Nakaya, Helder I" sort="Nakaya, Helder I" uniqKey="Nakaya H" first="Helder I" last="Nakaya">Helder I. Nakaya</name><affiliation wicri:level="4"><nlm:affiliation>Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Ho, Paulo Lee" sort="Ho, Paulo Lee" uniqKey="Ho P" first="Paulo Lee" last="Ho">Paulo Lee Ho</name><affiliation wicri:level="3"><nlm:affiliation>Bacteriology Service, BioIndustrial Division, Butantan Institute, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Bacteriology Service, BioIndustrial Division, Butantan Institute, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Silveira, Eduardo L V" sort="Silveira, Eduardo L V" uniqKey="Silveira E" first="Eduardo L V" last="Silveira">Eduardo L V. Silveira</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Immunology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Immunology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Farsky, Sandra Helena Poliselli" sort="Farsky, Sandra Helena Poliselli" uniqKey="Farsky S" first="Sandra Helena Poliselli" last="Farsky">Sandra Helena Poliselli Farsky</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Experimental Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: sfarsky@usp.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratory of Experimental Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j">Environmental pollution (Barking, Essex : 1987)</title><idno type="eISSN">1873-6424</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Hydroquinones (toxicity)</term><term>Immunity, Humoral (drug effects)</term><term>Influenza Vaccines</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Tobacco</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Hydroquinones (toxicité)</term><term>Immunité humorale ()</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tabac</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Hydroquinones</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunity, Humoral</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Hydroquinones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Influenza Vaccines</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Tobacco</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunité humorale</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tabac</term><term>Vaccins antigrippaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The influenza is a common viral infection that can be fatal, especially in high-risk groups such as children, pregnant women, elderly, and immune-deficient individuals. Vaccination is the most efficient approach to prevent the spreading of viral infection and promote individual and public health. In contrast, exposure to environmental pollutants such as cigarette smoke reduces the efficacy of vaccination. We investigated whether chronic exposure to hydroquinone (HQ), the most abundant compound of the tobacco particulate phase, could impair the adaptive immune responses elicited by influenza vaccination. For this, adult male C57BL/6 mice were daily exposed to either nebulized HQ or PBS for 1 h for a total of eight weeks. At weeks 6 and 8, the mice were primed and boosted with the trivalent influenza vaccine via IM respectively. Although the HQ exposure did not alter the body weight of the mice and the biochemical and hematological parameters, the pollutant increased the oxidative stress in splenocytes of immunized animals, modified the morphology of spleen follicles, and augmented the size of their lymph nodes. The lymphoid organs of HQ-exposed mice presented a similar number of vaccine-specific IgG-secreting cells, titers of vaccine-specific total IgG, and respective subclasses. Transcriptome studies with HQ, benzene, or cigarette smoke exposure were also analyzed. The genes up-regulated upon pollutant exposure were associated with neutrophil migration and were shown to be co-expressed with antibody-secreting cell genes. Therefore, these findings suggest that HQ exposure may trigger an immune-compensatory mechanism that enhances the humoral responses induced by influenza vaccination.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Fabris, Andre Luis" sort="Fabris, Andre Luis" uniqKey="Fabris A" first="André Luis" last="Fabris">André Luis Fabris</name></region><name sortKey="De Paula Silva, Marina" sort="De Paula Silva, Marina" uniqKey="De Paula Silva M" first="Marina" last="De Paula-Silva">Marina De Paula-Silva</name><name sortKey="Farsky, Sandra Helena Poliselli" sort="Farsky, Sandra Helena Poliselli" uniqKey="Farsky S" first="Sandra Helena Poliselli" last="Farsky">Sandra Helena Poliselli Farsky</name><name sortKey="Ho, Paulo Lee" sort="Ho, Paulo Lee" uniqKey="Ho P" first="Paulo Lee" last="Ho">Paulo Lee Ho</name><name sortKey="Nakaya, Helder I" sort="Nakaya, Helder I" uniqKey="Nakaya H" first="Helder I" last="Nakaya">Helder I. Nakaya</name><name sortKey="Nunes, Andre Vinicius" sort="Nunes, Andre Vinicius" uniqKey="Nunes A" first="Andre Vinicius" last="Nunes">Andre Vinicius Nunes</name><name sortKey="Rocha, Gho" sort="Rocha, Gho" uniqKey="Rocha G" first="Gho" last="Rocha">Gho Rocha</name><name sortKey="Schuch, Viviane" sort="Schuch, Viviane" uniqKey="Schuch V" first="Viviane" last="Schuch">Viviane Schuch</name><name sortKey="Silveira, Eduardo L V" sort="Silveira, Eduardo L V" uniqKey="Silveira E" first="Eduardo L V" last="Silveira">Eduardo L V. Silveira</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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